Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Adam24tm1Pmkf Name: ADAM metallopeptidase domain 24; targeted mutation 1, Paul Primakoff MGI ID: MGI:4437125 Gene: Adam24  Location: Chr8:41128118-41135238 bp, + strand  Genetic Position: Chr8, 23.89 cM Alliance: Adam24tm1Pmkf page

In vivo polyspermy with Adam24tm1Pmkf/Adam24tm1Pmkf male mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:157046
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first 576 amino acids have been eliminated by the insertion of a neomycin cassette by homologous recombination. The 88 KDa protein was absent on a western blot of mature sperm. (J:157046)

Generation of the Adam24tm1Pmkf allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam24 Mutation:	31 strains or lines available

Original:	J:157046 Zhu GZ, et al., Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Mol Reprod Dev. 2009 Nov;76(11):1106-14
All:	1 reference(s)