Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc26a7tm1Sole
Name:	solute carrier family 26, member 7; targeted mutation 1, Manoocher Soleimani
MGI ID:	MGI:4429559
Gene:	Slc26a7  Location: Chr4:14502430-14621805 bp, - strand  Genetic Position: Chr4, 6.24 cM
Alliance:	Slc26a7tm1Sole page

Germline Transmission:	Earliest citation of germline transmission: J:156969
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 were replaced by a neomycin selection cassette. These exons encode 168 amino acids. Northern blot analysis confirmed the absence of mRNA and the absence of protein was established immunologically. (J:156969)

Generation of the Slc26a7tm1Sole allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc26a7 Mutation:	50 strains or lines available

Original:	J:156969 Xu J, et al., Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem. 2009 Oct 23;284(43):29470-9
All:	6 reference(s)