Cttntm1.2Okab
Targeted Allele Detail
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| Symbol: |
Cttntm1.2Okab |
| Name: |
cortactin; targeted mutation 1.2, Shigeo Okabe |
| MGI ID: |
MGI:4418949 |
| Gene: |
Cttn Location: Chr7:143989468-144024743 bp, - strand Genetic Position: Chr7, 88.84 cM
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| Alliance: |
Cttntm1.2Okab page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:155986
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A single loxP site was introduced 0.5-kb downstream of Exon 4. A reporter fusion construct containing a FRT site, splice acceptor (derived from 0.6kb upstream of exon 6), the cDNA from exons 6-18, IRES, b-galactosidase-neo, polyA, FRT site and an additional loxP site were inserted within intron 5 by homologous recombination. The reporter construct and exon 5 were removed by flp- and cre- mediated recombination respectively. Western blotting showed absence of protein in fibroblasts.
(J:155986)
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Generation of the Cttntm1.1Okab and Cttntm1.2Okab alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cttn Mutation: |
28 strains or lines available
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| Original: |
J:155986 Tanaka S, et al., Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts. Genesis. 2009 Sep;47(9):638-46 |
| All: |
1 reference(s) |
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Analysis Tools
