Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rnf103tm1.1Thg
Name:	ring finger protein 103; targeted mutation 1.1, Tamotsu Hashimoto-Gotoh
MGI ID:	MGI:4410507
Synonyms:	kf-1-
Gene:	Rnf103  Location: Chr6:71470878-71487865 bp, + strand  Genetic Position: Chr6, 32.16 cM
Alliance:	Rnf103tm1.1Thg page

Germline Transmission:	Earliest citation of germline transmission: J:154853
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The targeting vector contains a diphtheria toxin cassette, a neo cassette in reverse orientation inserted 3' to exon 4 and loxP sites flanking the neo cassette and exon 4. Exon 4 includes coding sequences for the transmembrane regions, the ubiquitination site and zinc finger binding domain. Mice were crossed with mice carrying Tg(CAG-cre)12Miya to remove exon 4 and the neo cassette leaving a single loxP site downstream of exon 3. Protein was not detectable by Western blot and immunochemistry analyses. (J:154853) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rnf103 Mutation:	30 strains or lines available

Original:	J:154853 Tsujimura A, et al., Mice Lacking the kf-1 Gene Exhibit Increased Anxiety- but not Despair-Like Behavior. Front Behav Neurosci. 2008;2:4
All:	3 reference(s)