Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Fads2tm1Mtna Name: fatty acid desaturase 2; targeted mutation 1, Manabu T Nakamura MGI ID: MGI:4365366 Synonyms: Fads2- Gene: Fads2  Location: Chr19:10040129-10078867 bp, - strand  Genetic Position: Chr19, 6.36 cM, cytoband B Alliance: Fads2tm1Mtna page

Female Fads2tm1Mtna/Fads2tm1Mtna mice exhibit dermatitis, enlarged spleen and liver, and intestinal ulcer when fed a diet lacking delta-6 desaturase products Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:153293
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed. (J:153293)

Generation of the Fads2tm1Mtna allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fads2 Mutation:	19 strains or lines available

Original:	J:153293 Stroud CK, et al., Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. J Lipid Res. 2009 Apr 7;50:1871-1880
All:	8 reference(s)