Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Trex2tm1.2Coso
Name:	three prime repair exonuclease 2; targeted mutation 1.2, Concepcio Soler
MGI ID:	MGI:4355746
Gene:	Trex2  Location: ChrX:72477311-72478949 bp, - strand  Genetic Position: ChrX, 37.31 cM, cytoband A6
Alliance:	Trex2tm1.2Coso page

Germline Transmission:	Earliest citation of germline transmission: J:151766
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on skin extracts. (J:151766)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Trex2tm1.2Coso

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trex2 Mutation:	2 strains or lines available

Original:	J:151766 Parra D, et al., Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice. Cancer Res. 2009 Aug 15;69(16):6676-84
All:	3 reference(s)