Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Antxr2tm1.2Lepp
Name:	anthrax toxin receptor 2; targeted mutation 1.2, Stephen H Leppla
MGI ID:	MGI:4352944
Synonyms:	CMG2-
Gene:	Antxr2  Location: Chr5:98032547-98178876 bp, - strand  Genetic Position: Chr5, 47.77 cM, cytoband E3
Alliance:	Antxr2tm1.2Lepp page

Germline Transmission:	Earliest citation of germline transmission: J:150952
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 12, which encodes the transmembrane domain, and an frt flanked neo cassette and second loxP site were inserted downstream of exon 12. Cre mediated recombination then removed exon 12 and (when present) the neo cassette leaving behind a single loxP site. (J:150952)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Antxr2 Mutation:	43 strains or lines available

Original:	J:150952 Liu S, et al., Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
All:	6 reference(s)