Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Extl3tm1.1Okam
Name:	exostosin-like glycosyltransferase 3; targeted mutation 1.1, Hiroshi Okamoto
MGI ID:	MGI:3844734
Synonyms:	Extl3-
Gene:	Extl3  Location: Chr14:65289509-65387304 bp, - strand  Genetic Position: Chr14, 33.86 cM, cytoband D1
Alliance:	Extl3tm1.1Okam page

Germline Transmission:	Earliest citation of germline transmission: J:148348
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre mediated recombination of Extl3tm1Okam removed exon 2 and the neo cassette. HPLC analysis confirmed the absence of heparan sulfate derived disaccharides in homozygous embryos. (J:148348)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Extl3 Mutation:	37 strains or lines available

Original:	J:148348 Takahashi I, et al., Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem Biophys Res Commun. 2009 May 22;383(1):113-8
All:	1 reference(s)