Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tacr3tm1Jasi
Name:	tachykinin receptor 3; targeted mutation 1, Judith A Siuciak
MGI ID:	MGI:3841488
Synonyms:	NK3-, NK3R-
Gene:	Tacr3  Location: Chr3:134534768-134640340 bp, + strand  Genetic Position: Chr3, 62.47 cM, cytoband H2
Alliance:	Tacr3tm1Jasi page

Germline Transmission:	Earliest citation of germline transmission: J:147538
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRES-lacZ reporter and neomycin resistance cassette replaced exon 1. Gene inactivation was confirmed by a lack mRNA in homozygote cerebral cortex as determined by RT-PCR. (J:147538)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacr3 Mutation:	34 strains or lines available

Original:	J:147538 Siuciak JA, et al., Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits. Psychopharmacology (Berl). 2007 Oct;194(2):185-95
All:	4 reference(s)