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Hoxdtm17Ddu
Targeted Allele Detail
Summary
Symbol: Hoxdtm17Ddu
Name: homeobox D cluster; targeted mutation 17, Denis Duboule
MGI ID: MGI:3840830
Synonyms: HoxD(12-13)Fi
Gene: Hoxd  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47366
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe 5 Kb intergenic region between Hoxd13 and Hoxd12 was replaced with the corresponding 3 Kb sequence from zebrafish. A 5' floxed neo cassette was removed in vitro. Whole mount in situ hybridization confirmed reduced expression of Hoxd12 but normal expression of Hoxd11 and Hoxd13. (J:47366)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd Mutation:  0 strains or lines available
References
Original:  J:47366 Kondo T, et al., Control of colinearity in AbdB genes of the mouse HoxD complex. Mol Cell. 1998 Jan;1(2):289-300
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory