Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dhx58tm1Gnb
Name:	DExH-box helicase 58; targeted mutation 1, Glen N Barber
MGI ID:	MGI:3837303
Synonyms:	Lgp2-
Gene:	Dhx58  Location: Chr11:100585710-100595097 bp, - strand  Genetic Position: Chr11, 63.52 cM
Alliance:	Dhx58tm1Gnb page

Germline Transmission:	Earliest citation of germline transmission: J:146113
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 through 6 were replaced with a floxed neo cassette. The absence of protein expression following treatment with IFN-beta was confirmed by western blot analysis on mouse embryo fibroblasts. (J:146113)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dhx58 Mutation:	36 strains or lines available

Original:	J:146113 Venkataraman T, et al., Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol. 2007 May 15;178(10):6444-55
All:	2 reference(s)