Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kmt2etm1.1Hjf
Name:	lysine (K)-specific methyltransferase 2E; targeted mutation 1.1, H J Fehling
MGI ID:	MGI:3835538
Gene:	Kmt2e  Location: Chr5:23639439-23709233 bp, + strand  Genetic Position: Chr5, 10.33 cM, cytoband A3
Alliance:	Kmt2etm1.1Hjf page

Germline Transmission:	Earliest citation of germline transmission: J:145579
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 were removed by germ line, cre mediated. The absence of protein expression was confirmed by western blot analysis on testis and thymus extracts. (J:145579)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kmt2e Mutation:	105 strains or lines available

Original:	J:145579 Madan V, et al., Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood. 2009 Feb 12;113(7):1444-54
All:	3 reference(s)