Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myoz1tm1Eno
Name:	myozenin 1; targeted mutation 1, Eric N Olson
MGI ID:	MGI:3831744
Gene:	Myoz1  Location: Chr14:20699175-20706608 bp, - strand  Genetic Position: Chr14, 11.53 cM
Alliance:	Myoz1tm1Eno page

Germline Transmission:	Earliest citation of germline transmission: J:144597
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a lacZ reporter and a PGK-neomycin selection cassette. Western blot analysis confirmed the absence of gene expression in the gastrocnemius muscle. (J:144597)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myoz1 Mutation:	25 strains or lines available

Original:	J:144597 Frey N, et al., Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. J Clin Invest. 2008 Nov;118(11):3598-608
All:	1 reference(s)