Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dyrk3tm1Dowo
Name:	dual-specificity tyrosine phosphorylation regulated kinase 3; targeted mutation 1, Don M Wojchowski
MGI ID:	MGI:3831552
Gene:	Dyrk3  Location: Chr1:131056178-131065991 bp, - strand  Genetic Position: Chr1, 56.9 cM
Alliance:	Dyrk3tm1Dowo page

Germline Transmission:	Earliest citation of germline transmission: J:144586
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was replaced with a floxed neo cassette. This exon encodes the catalytic domain and a unique C-terminal region. Germ line, cre-mediated recombination was used to remove the neo cassette. The absence of transcript expression was confirmed by RT-PCR on extracts from early and late erythroblasts. (J:144586)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dyrk3 Mutation:	34 strains or lines available

Original:	J:144586 Bogacheva O, et al., DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. J Biol Chem. 2008 Dec 26;283(52):36665-75
All:	1 reference(s)