Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Dusp6tm1Jmol Name: dual specificity phosphatase 6; targeted mutation 1, Jeffery D Molkentin MGI ID: MGI:3827011 Gene: Dusp6  Location: Chr10:99099093-99103351 bp, + strand  Genetic Position: Chr10, 51.13 cM, cytoband C3 Alliance: Dusp6tm1Jmol page

Increased satellite cell numbers in Dusp6tm1Jmol/Dusp6tm1Jmol regenerating muscle following injury Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:142966
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All 3 exons were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein in the lung, spleen, thymus, and heart of homozygous mice. (J:142966)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dusp6 Mutation:	27 strains or lines available

Original:	J:142966 Maillet M, et al., DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. J Biol Chem. 2008 Nov 7;283(45):31246-55
All:	15 reference(s)