Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Epb41l5tm1Sia Name: erythrocyte membrane protein band 4.1 like 5; targeted mutation 1, Shinichi Aizawa MGI ID: MGI:3822451 Gene: Epb41l5  Location: Chr1:119472767-119576730 bp, - strand  Genetic Position: Chr1, 52.32 cM Alliance: Epb41l5tm1Sia page

Epb41l5tm1Sia/Epb41l5tm1Sia mice display mesodermal and epithelial-mesenchymal transition defects Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:142596
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A floxed construct containing lacZ and an FRT flanked neomycin selection cassette was inserted at the second ATG in the first coding exon. Expression of the lacZ reporter is very low. RT-PCR indicated the absence of mRNA and Western blot analysis indicated that no protein is produced. (J:142596)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epb41l5 Mutation:	46 strains or lines available

Original:	J:142596 Hirano M, et al., EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol. 2008 Sep 22;182(6):1217-30
All:	1 reference(s)