Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tgfbr3tm1.1Jba
Name:	transforming growth factor, beta receptor III; targeted mutation 1.1, Joey V Barnett
MGI ID:	MGI:3818438
Gene:	Tgfbr3  Location: Chr5:107254436-107437495 bp, - strand  Genetic Position: Chr5, 51.9 cM
Alliance:	Tgfbr3tm1.1Jba page

Germline Transmission:	Earliest citation of germline transmission: J:141344
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 of this locus encodes the N terminus, including a portion of the extracellular ligand binding domain. A floxed neo-cassette was placed upstream of exon 3 and a single loxP site was placed downstream of exon 3. Mice carrying the targeted mutation in the germline were crossed with cre-transgenic mice to remove exon 3 and the neo-cassette, leaving in its place a single loxP site. Ligand crosslinking with 125I-TGFbeta to embryonic fibroblasts isolated from homozygotes confirms loss of protein expression. (J:141344)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	86 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfbr3 Mutation:	50 strains or lines available

Original:	J:141344 Compton LA, et al., Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res. 2007 Oct 12;101(8):784-91
All:	3 reference(s)