Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ulk1tm1.1Thsn
Name:	unc-51 like kinase 1; targeted mutation 1.1, Craig B Thompson
MGI ID:	MGI:3808004
Synonyms:	Ulk1-, Ulk1tm1.1Kund
Gene:	Ulk1  Location: Chr5:110932354-110957963 bp, - strand  Genetic Position: Chr5, 53.7 cM, cytoband F
Alliance:	Ulk1tm1.1Thsn page

Germline Transmission:	Earliest citation of germline transmission: J:139213
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Ulk1tm1Kund heterozygotes were crossed with EIIa-Cre transgenic mice to generate a null allele by excising exons 1-3. There is no protein in homozygoous mouse embryonic fibroblasts as determined by Western blotting. (J:139213)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	87 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ulk1 Mutation:	87 strains or lines available

Original:	J:139213 Kundu M, et al., Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood. 2008 Aug 15;112(4):1493-502
All:	17 reference(s)