Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Napepldtm1.1Rpa
Name:	N-acyl phosphatidylethanolamine phospholipase D; targeted mutation 1.1, Richard D Palmiter
MGI ID:	MGI:3804925
Synonyms:	NAPE-PLD-
Gene:	Napepld  Location: Chr5:21867899-21906394 bp, - strand  Genetic Position: Chr5, 9.97 cM
Alliance:	Napepldtm1.1Rpa page

Germline Transmission:	Earliest citation of germline transmission: J:132692
Parent Cell Line:	AK18.1 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: LoxP sites flank exon 3. An Sv-Neo (SV40 promoter-neomycinphosphotransferase) gene is flanked by frt sites from removal by the action of FLPase. After removal of the Sv-Neo cassette by breeding with FLPer mice, exon 3 was removed in all cells by breeding with Mox2-Cre mice to generate heterozygous animals with one null NAPE-PLD allele. These mice were bred with C57BL/6 mice to remove the Mox2-Cre gene, and then bred together to generate mice homozygous for the NAPE-PLD-null allele. (J:132692)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Napepld Mutation:	24 strains or lines available

Original:	J:132692 Liu J, et al., Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology. 2008 Jan;54(1):1-7
All:	3 reference(s)