Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rtl1tm1Fuis
Name:	retrotransposon Gaglike 1; targeted mutation 1, Fumitoshi Ishino
MGI ID:	MGI:3776873
Gene:	Rtl1  Location: Chr12:109555627-109566764 bp, - strand  Genetic Position: Chr12, 60.38 cM
Alliance:	Rtl1tm1Fuis page

Germline Transmission:	Earliest citation of germline transmission: J:132647
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The open reading frame was replaced with a neo cassette that was subsequently removed by transient cre expression. The absence of transcript expression was confirmed by RT-PCR. This allele also results in the deletion of 6 of the up to 7 microRNAs located within the anti-sense strand of the gene, which include: Mirn127, Mirn136, Mirn431, Mirn433 (5' and 3') and Mirn434 (5' and 3'). (J:132647)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rtl1 Mutation:	78 strains or lines available

Original:	J:132647 Sekita Y, et al., Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet. 2008 Feb;40(2):243-8
All:	4 reference(s)