Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sirt4tm1Fwa
Name:	sirtuin 4; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:3769237
Synonyms:	Sirt4tm1Lgu
Gene:	Sirt4  Location: Chr5:115616069-115622784 bp, - strand  Genetic Position: Chr5, 56.1 cM, cytoband F
Alliance:	Sirt4tm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:129427
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 through 3 were replaced with a lacZ gene inserted in-frame after the first 21 bp of exon 1. The absence of protein product was confirmed by western blot analysis on brain, pancreas and liver extracts. (J:129427)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sirt4 Mutation:	37 strains or lines available

Original:	J:129427 Haigis MC, et al., SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 8;126(5):941-54
All:	15 reference(s)