Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpr83tm1.1Ayr
Name:	G protein-coupled receptor 83; targeted mutation 1.1, Alexander Y Rudensky
MGI ID:	MGI:3768257
Synonyms:	GPR83-
Gene:	Gpr83  Location: Chr9:14771506-14782085 bp, + strand  Genetic Position: Chr9, 4.4 cM, cytoband A2-A3
Alliance:	Gpr83tm1.1Ayr page

Germline Transmission:	Earliest citation of germline transmission: J:127791
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP element was inserted 347 bp upstream of exon 3, and a cassette containing a loxP site and a FRT-flanked neomycin cassette was inserted 703 bp downstream of exon 4. Chimeric mice were first mated to FLP deleter mice to remove the neomycin cassette, and subsequently to Cre-transgenic mice to remove the floxed alleles. Gene deletion was confirmed by lack of expression in regulatory T cells as determined by quantitative RT-PCR. (J:127791)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr83 Mutation:	23 strains or lines available

Original:	J:127791 Lu LF, et al., G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol Cell Biol. 2007 Dec;27(23):8065-72
All:	3 reference(s)