Apctm1.1Tno
Targeted Allele Detail
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Symbol: |
Apctm1.1Tno |
Name: |
APC, WNT signaling pathway regulator; targeted mutation 1.1, Tetsuo Noda |
MGI ID: |
MGI:3764940 |
Synonyms: |
Apc580D, Apc580delta |
Gene: |
Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
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Alliance: |
Apctm1.1Tno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:127452
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: One loxP site was inserted into intron 13 and the other, with a PGK-neo cassette, into intron 14. Exon 14 was excised by Cre mediated recombination, resulting in a nonsense frame-shift mutation. Excision of the exon was confirmed by RT-PCR and sequencing analysis of mRNA isolated from the large intestine. Western blot detected the truncated product (70 kDa).
(J:127452, J:156864)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Apc Mutation: |
154 strains or lines available
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Original: |
J:127452 Shibata H, et al., Alpha-catenin is essential in intestinal adenoma formation. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18199-204 |
All: |
3 reference(s) |
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