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Cerktm1Yiga
Targeted Allele Detail
Summary
Symbol: Cerktm1Yiga
Name: ceramide kinase; targeted mutation 1, Yasuyuki Igarashi
MGI ID: MGI:3764485
Synonyms: CerK-null
Gene: Cerk  Location: Chr15:86023329-86070342 bp, - strand  Genetic Position: Chr15, 40.52 cM
Alliance: Cerktm1Yiga page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127354
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exon 6 of the gene, which encodes for a diacylglycerol kinase-like catalytic domain. No enzymatic activity of the gene product was detected in brain tissue from homozygotic mice. (J:127354)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cerk Mutation:  24 strains or lines available
References
Original:  J:127354 Mitsutake S, et al., The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells. Biochem Biophys Res Commun. 2007 Nov 23;363(3):519-24
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory