Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trhrtm1Hzg
Name:	thyrotropin releasing hormone receptor; targeted mutation 1, Hongkui Zeng
MGI ID:	MGI:3763533
Gene:	Trhr  Location: Chr15:44059531-44099308 bp, + strand  Genetic Position: Chr15, 16.82 cM
Alliance:	Trhrtm1Hzg page

Germline Transmission:	Earliest citation of germline transmission: J:125915
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A retroviral vector containing an SA-stop-IRES-rtTA and floxed neo cassette was inserted between exons 1 and 2. The absence of transcript in the pituitary and brain was confirmed by RT-PCR. (J:125915)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trhr Mutation:	31 strains or lines available

Original:	J:125915 Zeng H, et al., Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Mol Endocrinol. 2007 Nov;21(11):2795-804
All:	2 reference(s)