Tead2tm1.1Mldp
Targeted Allele Detail
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| Symbol: |
Tead2tm1.1Mldp |
| Name: |
TEA domain family member 2; targeted mutation 1.1, Melvin DePamphilis |
| MGI ID: |
MGI:3763367 |
| Synonyms: |
Tead2- |
| Gene: |
Tead2 Location: Chr7:44865216-44882892 bp, + strand Genetic Position: Chr7, 29.19 cM, cytoband B5
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| Alliance: |
Tead2tm1.1Mldp page
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Exencephaly in Tead2tm1.1Mldp/Tead2tm1.1Mldp embryos at E13.5
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:127233
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Modified regulatory region, Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: The enhancer located upstream of exon 2, exon 2 and exon 3 were removed by cre-mediated recombination. These regions are responsible for encoding the N-terminal 99 amino acids of the protein thereby removing the translation initiation site and 82% of the TEA domain. Reduction in transcript production was confirmed by northern blot analysis on RNA extracted from lungs.
(J:127233)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tead2 Mutation: |
31 strains or lines available
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| Original: |
J:127233 Kaneko KJ, et al., Transcription factor TEAD2 is involved in neural tube closure. Genesis. 2007 Sep;45(9):577-87 |
| All: |
2 reference(s) |
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Analysis Tools
