Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itgavtm2.1Hyn
Name:	integrin alpha V; targeted mutation 2.1, Richard Hynes
MGI ID:	MGI:3759837
Synonyms:	alphav-
Gene:	Itgav  Location: Chr2:83554796-83637261 bp, + strand  Genetic Position: Chr2, 49.33 cM
Alliance:	Itgavtm2.1Hyn page

Germline Transmission:	Earliest citation of germline transmission: J:94376
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 4 was removed by cre-mediated recombination to create a null allele. Absence of protein expression was confirmed by FACS analysis of macrophages and splenocytes. (J:94376, J:125508)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

17 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgav Mutation:	53 strains or lines available

Original:	J:94376 McCarty JH, et al., Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-176
All:	3 reference(s)