Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cyldtm1Jdgl
Name:	CYLD lysine 63 deubiquitinase; targeted mutation 1, Jian-Dong Li
MGI ID:	MGI:3722146
Synonyms:	Cyld-
Gene:	Cyld  Location: Chr8:89423675-89478573 bp, + strand  Genetic Position: Chr8, 43.51 cM
Alliance:	Cyldtm1Jdgl page

Germline Transmission:	Earliest citation of germline transmission: J:124327
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with an IRES-lacZ/MC1-neo cassette. Absence of wild-type transcript was confirmed by RT-PCR. (J:124327)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyld Mutation:	43 strains or lines available

Original:	J:124327 Lim JH, et al., Tumor Suppressor CYLD Regulates Acute Lung Injury in Lethal Streptococcus pneumoniae Infections. Immunity. 2007 Aug;27(2):349-60
All:	7 reference(s)