Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ikbketm1Tman
Name:	inhibitor of kappaB kinase epsilon; targeted mutation 1, Tom Maniatis
MGI ID:	MGI:3707541
Synonyms:	Ikbke-
Gene:	Ikbke  Location: Chr1:131182337-131207339 bp, - strand  Genetic Position: Chr1, 56.93 cM
Alliance:	Ikbketm1Tman page

Germline Transmission:	Earliest citation of germline transmission: J:119791
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129 and C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4-6 of the targeted gene were replaced with a PGK-neo cassette. Mice show a complete loss of the endogenous kinase function in lung, spleen, and embryonic fibroblasts. (J:119791)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ikbke Mutation:	55 strains or lines available

Original:	J:119791 Tenoever BR, et al., Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science. 2007 Mar 2;315(5816):1274-8
All:	21 reference(s)