Summary | Mutation origin | Mutation description | Tumor data | Find Mice (IMSR) | References

Symbol:	Rbl2tm1Htr
Name:	RB transcriptional corepressor like 2; targeted mutation 1, Hein te Riele
MGI ID:	MGI:3703250
Synonyms:	p130-
Gene:	Rbl2  Location: Chr8:91796685-91850472 bp, + strand  Genetic Position: Chr8, 44.25 cM
Alliance:	Rbl2tm1Htr page

Germline Transmission:	Earliest citation of germline transmission: J:66166
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A Pgk-puromycin cassette was introduced into codon 405, which is in the A-domain of the pocket region. (J:66166)

List all tumor models in MMHCdb carrying Rbl2tm1Htr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbl2 Mutation:	52 strains or lines available

Original:	J:66166 Dannenberg JH, et al., Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 2000 Dec 1;14(23):3051-64
All:	4 reference(s)