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Dgcr2tm1Ais
Targeted Allele Detail
Summary
Symbol: Dgcr2tm1Ais
Name: DiGeorge syndrome critical region gene 2; targeted mutation 1, Arthur I Skoultchi
MGI ID: MGI:3702624
Synonyms: Idd-
Gene: Dgcr2  Location: Chr16:17658219-17709592 bp, - strand  Genetic Position: Chr16, 11.05 cM, cytoband A-B1
Alliance: Dgcr2tm1Ais page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64380
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Duplication, Insertion
  Dgcr2tm1Ais involves 1 genes/genome features (Dgcr2) View all
 
Mutation detailsA targeting vector containing a PGK promoter, a loxP site and a neomycin resistance gene was inserted into the DiGeorge syndrome critical region gene 2, resulting in the loss of exons 4 and 5. (J:64380)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dgcr2 Mutation:  24 strains or lines available
References
Original:  J:64380 Puech A, et al., Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10090-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory