Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp53inp1tm1Acar
Name:	transformation related protein 53 inducible nuclear protein 1; targeted mutation 1, Alice Carrier
MGI ID:	MGI:3700974
Synonyms:	inp1-, Trnp53-
Gene:	Trp53inp1  Location: Chr4:11156441-11174379 bp, + strand  Genetic Position: Chr4, 5.03 cM, cytoband A1-A2
Alliance:	Trp53inp1tm1Acar page

Germline Transmission:	Earliest citation of germline transmission: J:118867
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-4 were replaced with a floxed neomycin resistance cassette. The neo was subsequently removed as the targeting vector also contained a cre recombinase gene under the control of the testes-specific angiotensin-converting enzyme gene promoter. RT-PCR confirmed absence of transcript in mutant spleens. (J:118867)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

List all tumor models in MMHCdb carrying Trp53inp1tm1Acar

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Trp53inp1 Mutation:	21 strains or lines available

Original:	J:118867 Gommeaux J, et al., Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Mol Cell Biol. 2007 Mar;27(6):2215-28
All:	9 reference(s)