Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rdh12tm1.1Cahb
Name:	retinol dehydrogenase 12; targeted mutation 1.1, Christian A Hubner
MGI ID:	MGI:3700208
Gene:	Rdh12  Location: Chr12:79255687-79269438 bp, + strand  Genetic Position: Chr12, 35.51 cM, cytoband D2
Alliance:	Rdh12tm1.1Cahb page

Germline Transmission:	Earliest citation of germline transmission: J:118293
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A floxed neo was cassette inserted into intro 3 and an additional loxP site was placed in the 5' region of the gene via homologous recombination. All of the floxed sequence was then removed by transient Cre expression in the ES cells. Western blot analysis confirmed absence of protein expression in whole eye lysates from homozygous mice. (J:118293)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdh12 Mutation:	17 strains or lines available

Original:	J:118293 Kurth I, et al., Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. Mol Cell Biol. 2007 Feb;27(4):1370-9
All:	3 reference(s)