Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abcc4tm1Kruh
Name:	ATP-binding cassette, sub-family C member 4; targeted mutation 1, Gary D Kruh
MGI ID:	MGI:3697373
Synonyms:	Mpr4-
Gene:	Abcc4  Location: Chr14:118720104-118943631 bp, - strand  Genetic Position: Chr14, 62.24 cM
Alliance:	Abcc4tm1Kruh page

Germline Transmission:	Earliest citation of germline transmission: J:117326
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Genomic sequence encoding amino acids 77 to 101 was replaced with a neomycin resistance cassette. Absence of protein was confirmed in Western blot analysis. (J:117326)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc4 Mutation:	151 strains or lines available

Original:	J:117326 Belinsky MG, et al., Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res. 2007 Jan 1;67(1):262-8
All:	1 reference(s)