Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Meltftm1Drrn
Name:	melanotransferrin; targeted mutation 1, Des R Richardson
MGI ID:	MGI:3691276
Synonyms:	MTf-
Gene:	Meltf  Location: Chr16:31697628-31717838 bp, + strand  Genetic Position: Chr16, 22.4 cM, cytoband B3
Alliance:	Meltftm1Drrn page

Germline Transmission:	Earliest citation of germline transmission: J:115256
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 2-4 were replaced with a floxed neo gene and exon 1 was reversed. The neo was subsequently removed from the locus via cre-mediated recombination. Western blot failed to detect protein in mutant testis and intestine. (J:115256)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Meltf Mutation:	46 strains or lines available

Original:	J:115256 Sekyere EO, et al., Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo. Blood. 2006 Apr 1;107(7):2599-601
All:	3 reference(s)