Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pot1atm1.1Schg
Name:	protection of telomeres 1A; targeted mutation 1.1, Sandy Chang
MGI ID:	MGI:3665307
Synonyms:	Pot1adelta
Gene:	Pot1a  Location: Chr6:25743939-25809280 bp, - strand  Genetic Position: Chr6, 11.65 cM
Alliance:	Pot1atm1.1Schg page

Germline Transmission:	Earliest citation of germline transmission: J:112184
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion     Cre-mediated expression removes exons 4 and 5. RT-PCR did not detect transcript in mutants. (J:112184)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pot1a Mutation:	42 strains or lines available

Original:	J:112184 Wu L, et al., Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell. 2006 Jul 14;126(1):49-62
All:	1 reference(s)