Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sh3bp2tm1Geha
Name:	SH3-domain binding protein 2; targeted mutation 1, Raif S Geha
MGI ID:	MGI:3664088
Synonyms:	3bp2-
Gene:	Sh3bp2  Location: Chr5:34683182-34720985 bp, + strand  Genetic Position: Chr5, 17.89 cM
Alliance:	Sh3bp2tm1Geha page

Germline Transmission:	Earliest citation of germline transmission: J:110319
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A vector was designed to replace the 3' half of exon 6 and all of exons 7 through 13 with a neomycin resistance cassette. This sequence includes the proline-rich region and the SH2 domain. Transcript was not detected in mutant mice. (J:110319)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh3bp2 Mutation:	35 strains or lines available

Original:	J:110319 de la Fuente MA, et al., 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol. 2006 Jul;26(14):5214-25
All:	1 reference(s)