Metap2tm1.2Ccr
Targeted Allele Detail
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Symbol: |
Metap2tm1.2Ccr |
Name: |
methionine aminopeptidase 2; targeted mutation 1.2, Craig M Crews |
MGI ID: |
MGI:3663890 |
Synonyms: |
MAP2D |
Gene: |
Metap2 Location: Chr10:93694351-93732952 bp, - strand Genetic Position: Chr10, 48.69 cM
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Alliance: |
Metap2tm1.2Ccr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:111701
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Two loxP sites were inserted into the 5' UTR and the first intron via homologous recombination. A neomycin resistance gene flanked by two frt sequences was also introduced into the intron. Floxed mice with the neomycin resistance gene were crossed with Tg(ACTB-cre)2Mrt mice to remove the floxed exon 1.
(J:111701)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Metap2 Mutation: |
32 strains or lines available
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Original: |
J:111701 Yeh JR, et al., Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10379-84 |
All: |
1 reference(s) |
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