Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hsh2dtm1Viss
Name:	hematopoietic SH2 domain containing; targeted mutation 1, Virginia Smith Shapiro
MGI ID:	MGI:3662663
Synonyms:	ALX KO
Gene:	Hsh2d  Location: Chr8:72943512-72954802 bp, + strand  Genetic Position: Chr8, 34.87 cM
Alliance:	Hsh2dtm1Viss page

Germline Transmission:	Earliest citation of germline transmission: J:111408
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exons 2 and 3. These exons encoded the ATG and the SH2 domain FLVR motif. Western blot failed to detect protein in mutants. (J:111408)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsh2d Mutation:	57 strains or lines available

Original:	J:111408 Perchonock CE, et al., Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX. Mol Cell Biol. 2006 Aug;26(16):6005-15
All:	2 reference(s)