Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irak1tm1Wpfl
Name:	interleukin-1 receptor-associated kinase 1; targeted mutation 1, Wai-Ping Fung-Leung
MGI ID:	MGI:3654141
Gene:	Irak1  Location: ChrX:73057520-73067524 bp, - strand  Genetic Position: ChrX, 37.61 cM
Alliance:	Irak1tm1Wpfl page

Germline Transmission:	Earliest citation of germline transmission: J:110860
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was used to replace exons 5-7 with a neomycin resistance gene. Protein was not detected in mutant MEFs. (J:110860)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irak1 Mutation:	16 strains or lines available

Original:	J:110860 Kanakaraj P, et al., Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med. 1998 Jun 15;187(12):2073-9
All:	2 reference(s)