Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myctm2Dmlo
Name:	myelocytomatosis oncogene; targeted mutation 2, Dominique Morello
MGI ID:	MGI:3640384
Synonyms:	Delta3'myc
Gene:	Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance:	Myctm2Dmlo page

Germline Transmission:	Earliest citation of germline transmission: J:70610
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: This allele contains a 159-nt long human MYC sequence encoding the carboxy terminal part of the protein in place of the corresponding mouse sequence. The allele contained a floxed neomycin resistance cassette with an RNA polymerase II promoter but without a polyA sequence immediately downstream of the MYC stop codon, which was subsequently removed by transient expression of cre recombinase. (J:70610)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:	42 strains or lines available

Original:	J:70610 Langa F, et al., Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited. Oncogene. 2001 Jul 19;20(32):4344-53
All:	1 reference(s)