Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hmgcltm1Gam
Name:	3-hydroxy-3-methylglutaryl-Coenzyme A lyase; targeted mutation 1, Grant A Mitchell
MGI ID:	MGI:3640351
Synonyms:	HL-
Gene:	Hmgcl  Location: Chr4:135673759-135689928 bp, + strand  Genetic Position: Chr4, 68.14 cM
Alliance:	Hmgcltm1Gam page

Germline Transmission:	Earliest citation of germline transmission: J:52117
Parent Cell Line:	CGR8 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exon 2 was replaced by a neomycin resistance gene. (J:52117)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmgcl Mutation:	15 strains or lines available

Original:	J:52117 Wang SP, et al., 3-Hydroxy-3-methylglutaryl-CoA lyase (HL): gene targeting causes prenatal lethality in HL-deficient mice. Hum Mol Genet. 1998 Dec;7(13):2057-62
All:	1 reference(s)