Trp53bp2tm1Xlu
Targeted Allele Detail
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Symbol: |
Trp53bp2tm1Xlu |
Name: |
transformation related protein 53 binding protein 2; targeted mutation 1, Xin Lu |
MGI ID: |
MGI:3625686 |
Synonyms: |
ASPP2, ASPP2 deltaexon3 |
Gene: |
Trp53bp2 Location: Chr1:182236737-182289997 bp, + strand Genetic Position: Chr1, 84.93 cM
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Alliance: |
Trp53bp2tm1Xlu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:108701
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Parent Cell Line: |
IT2 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Hypomorph, Modified isoform(s)) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector replaced exon 3. RT-PCR of brain tissue from E13.5 homozygous mutant embryos did not detect 368 bp wild-type product but did detect a 268-bp product. Western analyses using polyclonal antibodies to either N-terminal or mid-protein sequences did not detect protein in brain tissue from homozygous mutant E13.5 embryos.
The exon 3 deletion is an in-frame deletion causing only the major isoform of Trp53bp2 to be deleted completely; low levels of shorter forms of Trp53bp2 can be expressed. Therefore Trp53bp23 acts as a hypomorphic allele.
(J:108701, J:240594)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trp53bp2 Mutation: |
52 strains or lines available
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Original: |
J:108701 Vives V, et al., ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev. 2006 May 15;20(10):1262-7 |
All: |
8 reference(s) |
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