Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hipk2tm1Hko
Name:	homeodomain interacting protein kinase 2; targeted mutation 1, Haruhiko Koseki
MGI ID:	MGI:3624127
Synonyms:	Hipk2-
Gene:	Hipk2  Location: Chr6:38671325-38853099 bp, - strand  Genetic Position: Chr6, 17.85 cM, cytoband B
Alliance:	Hipk2tm1Hko page

Germline Transmission:	Earliest citation of germline transmission: J:106931
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace sequence containing the start codon and the flanking intronic region with the neomycin resistance gene. RT-PCR demonstrated a lack of transcript in mutants. Western blot showed no wild-type protein, but absence of C-terminally truncated proteins could not be concluded. (J:106931)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hipk2 Mutation:	53 strains or lines available

Original:	J:106931 Isono K, et al., Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol. 2006 Apr;26(7):2758-71
All:	5 reference(s)