Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kif2atm1Noh
Name:	kinesin family member 2A; targeted mutation 1, Nobutaka Hirokawa
MGI ID:	MGI:3623680
Synonyms:	Kif2a-, Kif2aGt(Betageo)1Noh
Gene:	Kif2a  Location: Chr13:107095504-107158634 bp, - strand  Genetic Position: Chr13, 58.06 cM, cytoband F
Alliance:	Kif2atm1Noh page

Germline Transmission:	Earliest citation of germline transmission: J:107737
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A betageo replaced 0.9 kb coding region of the ATP binding consensus P loop of the motor domain by a promoter gene trap strategy. The vector was designed to create a frame shift and also disrupt the beta splicing isoform. Western blot confirmed ablation of protein. (J:107737)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kif2a Mutation:	27 strains or lines available

Original:	J:107737 Homma N, et al., Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell. 2003 Jul 25;114(2):229-39
All:	4 reference(s)