Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plp1tm3Wst
Name:	proteolipid protein (myelin) 1; targeted mutation 3, Wilhelm Stoffel
MGI ID:	MGI:3617313
Synonyms:	dm20only
Gene:	Plp1  Location: ChrX:135723420-135740482 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Alliance:	Plp1tm3Wst page

Germline Transmission:	Earliest citation of germline transmission: J:105188
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: A targeting vector was designed to delete 105 bp of exon 3. Transcription of Plp1 was reduced by 50-60%, however, DM20 protein was expressed at wild-type levels. (J:105188)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:	19 strains or lines available

Original:	J:105188 Sporkel O, et al., Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development. Glia. 2002 Jan;37(1):19-30
All:	1 reference(s)