Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Baxtm1Ofxa
Name:	BCL2-associated X protein; targeted mutation 1, Osborne FX Almeida
MGI ID:	MGI:3613737
Synonyms:	bax -
Gene:	Bax  Location: Chr7:45111121-45116322 bp, - strand  Genetic Position: Chr7, 29.32 cM, cytoband B5
Alliance:	Baxtm1Ofxa page

Germline Transmission:	Earliest citation of germline transmission: J:61471
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector containing a lacZ gene and an RSV-neomycin resistance cassette replaced most of the protein coding sequence in the first four exons. Western blot analysis did not detect protein in hippocampi from homozygous mutant mice. (J:61471)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bax Mutation:	24 strains or lines available

Original:	J:61471 Almeida OF, et al., Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 2000 Apr;14(5):779-90
All:	1 reference(s)