Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppp2catm1Gotz
Name:	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; targeted mutation 1, Jurgen Gotz
MGI ID:	MGI:3613579
Synonyms:	Calpha-, PP2A Calpha-
Gene:	Ppp2ca  Location: Chr11:51989651-52013576 bp, + strand  Genetic Position: Chr11, 31.86 cM
Alliance:	Ppp2catm1Gotz page

Germline Transmission:	Earliest citation of germline transmission: J:50519
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An 8.1 kb neomycin resistance cassette containing a transcription terminating upstream mouse sequence (UMS) element replaced the promoter, exon 1, and part of intron 1. Northern blot analyses of total brain RNA from heterozygous mutant mice using antisense oligonucleotide probes specific for exon 6 and exon 7 did not detect aberrant mRNA transcribed from the mutant allele. Whole mount immunohistochemical studies using antisera directed against the first 20 amino acids of the protein, and which does not cross react with the Cbeta subunit, did not detect protein in homozygous mutant E7.5 embryos. (J:50519)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp2ca Mutation:	25 strains or lines available

Original:	J:50519 Gotz J, et al., Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12370-5
All:	2 reference(s)