Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tlr1tm1Aki
Name:	toll-like receptor 1; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:3609369
Synonyms:	Tlr1-
Gene:	Tlr1  Location: Chr5:65082022-65090906 bp, - strand  Genetic Position: Chr5, 33.53 cM
Alliance:	Tlr1tm1Aki page

Germline Transmission:	Earliest citation of germline transmission: J:103395
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced a portion of an exon containing amino acids 575-795 of the locus, sequence encoding the transmembrane and cytoplasmic regions of the protein. Northern blot failed to detect transcript in mutants. (J:103395)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr1 Mutation:	50 strains or lines available

Original:	J:103395 Takeuchi O, et al., Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002 Jul 1;169(1):10-4
All:	31 reference(s)