Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Insig2tm1Mbjg
Name:	insulin induced gene 2; targeted mutation 1, Joseph L Goldstein
MGI ID:	MGI:3603525
Synonyms:	Insig-2-, Insig2-, Insig2tm1Jlg
Gene:	Insig2  Location: Chr1:121232082-121260318 bp, - strand  Genetic Position: Chr1, 52.91 cM, cytoband E2
Alliance:	Insig2tm1Mbjg page

Germline Transmission:	Earliest citation of germline transmission: J:101203
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A polIIsneopA cassette was inserted to replace exons 2 and 3, which encode the first 123 of 225 amino acids. Northern blot and immunoblot failed to detect wild-type transcript and protein, respectively. An aberrant transcript was detected, possibly due to an initiation site in exons 1a or 1b and splicing directly to exon 4, 5 or 6. In such a transcript, the first available start codon is in exon 5, and, if translated, this transcript would yield a 23 amino-acid peptide. (J:101203)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Insig2 Mutation:	15 strains or lines available

Original:	J:101203 Engelking LJ, et al., Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005 Sep;115(9):2489-98
All:	8 reference(s)